师资队伍

COLLEGE OF LIFE SCIENCES
师资概况
专家人才
植物生物学
微生物学
生化与分子
动物生物学
实验中心
兼职教授
退休教授
师德师风
教师风采
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高级职称

闫新/教授

发布时间:2022年10月10日 17:05 | 编辑:成丹 | 作者:

联系方式

Tele: 13601585491

Email: yanxin@njau.edu.cn

教育背景

2000.9-2004.6,美高梅mgm1888网站,理学学士

2004.9-2008.12,美高梅mgm1888网站,微生物学博士

工作经历

2009.4-2011.12,美高梅mgm1888网站生科院微生物学系,讲师

2012.1-2016.12,美高梅mgm1888网站生科院微生物学系,副教授

2017.1-,美高梅mgm1888网站生科院微生物学系,教授、博导

2014.8-2015.8University of WashingtonUW),访问学者

学术兼职

中国微生物学会普通微生物学专业委员会委员

中国生物工程学会一碳生物技术专业委员会委员

江苏省微生物学会青年工作委员会委员

奖励

12017大北农青年学者奖

2)获863“青年科学家专题资助

教学情况

主讲微生物学基础微生物学硕士生研究班讨论

研究方向

1)微生物降分解农药等有毒污染物的分子机制及微生物修复

2)芽孢杆菌重组蛋白表达系统的开发及酶制剂生产

3)好氧嗜甲烷菌同化甲烷的分子机理及应用

已主持的项目

1国家基金面上:甲烷氧化菌介导的氨氧化作用的分子机制(32270127),2023.01-2026.12

2国家基金面上:细菌代谢二甲酚的分子机制研究(31970099),2020.01-2023.12

3国家基金面上:MmoDMmoGsMMO合成中的作用及机理(31770125),2018.1-2021.12

4国家基金面上:菌株Rhodococcus sp. YL-1降解杀虫剂噻嗪酮的途径及其分子机制(31470225),2015.1-2018.12

5国家基金青年:基于基因组测序的苯基脲类除草剂的细菌降解分子机理研究(31000060),2011.1-2013.12

6863“青年科学家专题:基于新型表达模块的芽孢杆菌表达平台的开发与应用(SS2014AA020543),2014.1-2016.12

7国家重点研发:塑料高效生物解聚的关键技术(2021YFC2103600),2021.12-2024.11(课题骨干)

8国家重点研发:人造蛋白质合成的细胞设计构建及应用(2019YFA0905200),2020.1-2024.12(课题骨干)

9国家重点研发:稻田典型农药多界面迁移规律及生源要素耦合的生物转化机制(2016YFD0800203),2017.1-2020.12(课题骨干)

10江苏省基金:稻田土著细菌降解噻嗪酮的途径及关键降解酶基因(BK20141366),2014.7-2016.7

11江苏省支撑:太湖地区稻田土壤中DDT和噻嗪酮等农药污染的微生物修复关键技术应用与示范(BE2009670),2009.7-2012.7

12横向课题:枯草芽孢杆菌无抗基因整合及高效表达,2014-2016

代表性论文(*通讯作者)

[1] Minggen Cheng, Dongmei Pei, Lian He, Qiang Fei, Xin Yan*. Cre/lox-Mediated CRISPRi Library Reveals Core Genome of a Type I Methanotroph Methylotuvimicrobium buryatense 5GB1C. Appl Environ Microbiol. 2023; 89(1):e0188322.

[2] Panpan Wu, Qing Tao, Yuxuan Liu, Caiting Zeng, Yu Li, Xin Yan*. Efficient secretion of mussel adhesion proteins using a chaperone protein Spy as fusion tag in Bacillus subtilis. Biotechnol J. 2023:e2200582.

[3] Bin Ye, Qing Tao, Xin Yan*. A transposon system for random insertion of a gene expression cassette into the chromosome of Bacillus subtilis. J Biotechnol. 2023; 361:66-73.

[4] Junbin Ji, Caiting Zeng, Panpan Wu, Yuying Wang, Xueting Chen, Xin Yan*. Improved Whole-Cell Biocatalyst for the Synthesis of Vitamin E Precursor 2,3,5-Trimethylhydroquinone. J Agric Food Chem. 2023;71(2):1162-1169.

[5] Junbin Ji , Minggen Cheng, Xin Yan*. Characterization of the 2,6-Dimethylphenol Monooxygenase MpdAB and Evaluation of Its Potential in Vitamin E Precursor Synthesis. Applied and Environmental Microbiology. 2022;88(8):e0011022.

[6] Cheng, Minggen; Pei, Dongmei; He, Xiangrong; Liu, Yongchuang; Zhu, Pingping; Yan, Xin*; The operon encoding hydrolytic dehalogenation of 4-chlorobenzoate is transcriptionally regulated by the TetR-type repressor FcbR and its ligand 4-chlorobenzoyl coenzyme A, Applied and Environmental Microbiology, 2021, 87(6)20.

[7] Liu, Yongchuang; He, Xiangrong; Zhu, Pingping; Cheng, Minggen; Hong, Qing; Yan, Xin*; pheSAG Based Rapid and Efficient Markerless Mutagenesis in Methylotuvimicrobium, Frontiers in Microbiology, 2020, 11441.

[8] Ji, Junbin; Zhang, Yanting; Liu, Yongchuang; Zhu, Pingping; Yan, Xin*; Biodegradation of plastic monomer 2,6-dimethylphenol by Mycobacterium neoaurum B5-4, Environmental Pollution, 2020, 258113793.

[9] Leizhen Zhao, Bin Ye, Qi Zhang, Dan Cheng, Chaoyang Zhou, Shan Cheng, Xin Yan*. Construction of second generation protease‐deficient hosts of Bacillus subtilis for secretion of foreign proteins. Biotechnology and Bioengineering. 2019. DOI: 10.1002/bit.26992

[10] Zhou C, Ye B, Cheng S, Zhao L, Liu Y, Jiang J, Yan X*. Promoter engineering enables overproduction of foreign proteins from a single copy expression cassette in Bacillus subtilis. Microb Cell Fact. 2019. 18(1):111. doi: 10.1186/s12934-019-1159-0.

[11] Xin Yan#, Junwei Huang#, Xihui Xu, Dian Chen, Xiangting Xie, Qing Tao, Jian He, Jiandong Jiang*. Enhanced and Complete Removal of Phenylurea Herbicides by Combinational Transgenic Plant-Microbe Remediation. Applied and Environmental Microbiology, 2018, 84:e00273-18. (Spotlight article)

[12] Xin Yan, Wen Jin, Guang Wu, Wankui Jiang, Zhangong Yang, Jumbin Ji, Jiguo Qiu, Jian He, Jiandong Jiang, Qing Hong*. Hydrolase CehA and Monooxygenase CfdC Are Responsible for Carbofuran Degradation in Sphingomonas sp. Strain CDS-1. Applied and Environmental Microbiology, 2018, DOI:10.1128/AEM.00805-18.

[13] Xueting Chen, Junbin Ji, Leizhen Zhao, Weiwu Wang, Jian He, Jiandong Jiang, Qing Hong, Xin Yan*. Molecular mechanism and genetic determinants of buprofezin degradation. Applied and Environmental Microbiology, 2017, 83:e00868-17. (Spotlight article)

[14] Minggen Cheng#, Qiang Meng#, Youjian Yang#, Cuiwei Chu, Qing Chen, Yi Li, Dan Cheng, Qing Hong, Xin Yan*, Jian He. The Two-Component Monooxygenase MeaXY Initiates the Downstream Pathway of Chloroacetanilide Herbicide Catabolism in Sphingomonads. Applied and Environmental Microbiology, 2017, 83(7): e03241-16. (Spotlight article)

[15] Xin Yan, Tao Gu, Zhongquan Yi, Junwei Huang, Xiaowei Liu, Ji Zhang, Xihui Xu, Zhihong Xin, Qing Hong, Jian He, Jim C. Spain, Shunpeng Li, Jiandong Jiang*. Comparative Genomic Analysis of Isoproturon-mineralizing sphingomonads Reveals the Isoproturon Catabolic Mechanism. Environmental Microbiology, 2016, 18(12): 4888-4906.

[16] Xin Yan*, Frances Chu, Aaron W. Puri, Yanfen Fu and Mary E. Lidstrom. Electroporation-Based Genetic Manipulation In Type I Methanotrophs. Applied and Environmental Microbiology, 2016, 82:7 2062-2069.

[17] Tao Gu, Chaoyang Zhou, Sebastian R. Sørensen, Ji Zhang, Jian He, Peiwen Yu, Xin Yan* and Shunpeng Li. The Novel Bacterial N-Demethylase PdmAB Is Responsible for the Initial Step of N,N-Dimethyl-Substituted Phenylurea Herbicide Degradation. Applied and Environmental Microbiology, 2013, 79(24): 7846-7856.

[18] Xin Yan, Hao-Jie Yu, Qing Hong, and Shun-Peng Li*. Cre/lox System and PCR-Based Genome Engineering in Bacillus subtilis. Applied and Environmental Microbiology, 2008, 74(17): 5556-5562.



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